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有报道多种汉方药可改善自身免疫性疾病患者的发病,然而其作用方式尚不清楚。本次以移植物抗宿主反应(GVHR)鼠、狼疮模型鼠(MRL MP-lpr/lpr)观察了9种汉方方剂对免疫复合物(ICs)的清除作用。 实验用汉方方剂为当归芍药散(TSS)、四逆散(SGS)、十全大补汤(JTT)、归脾汤(KHT)、桂枝人参汤(KNT)、加味四物汤(KST)、猪苓汤(CRT)、柴苓汤(SRT)与桂枝茯苓丸(KBG)。 ①汉方方剂对GVHR鼠的作用:按改良Rolink程序诱发GVHR.即向受体鼠F1(BDF1)注射亲代供体鼠(C57BL’6)的脾细胞3次,间隔6天,其后引发GVHR,循环免疫复合物(CICs)增加。经口给予6种汉方方剂TSS、SGS、JTT、KHT、KNT、KST,可显
It has been reported that a variety of Kampo medicine can improve the incidence of autoimmune diseases, but its mode of action is not yet clear. The removal of immune complexes (ICs) from 9 kinds of Chinese herbs was observed in the GVHR and MRL MP-lpr/lpr mice. The Han Fang formula used in the experiment was Danggui Shaoyao Powder (TSS), Sini Powder (SGS), Shiquan Datong Decoction (JTT), Guipi Decoction (KHT), Guizhi Ginseng Decoction (KNT), Jiawei Siwu Decoction (KST). ), Pork soup (CRT), Scutellaria decoction (SRT) and Guizhi Fuling Pill (KBG). 1 Effect of Chinese Herbal Formula on GVHR mice: GVHR induced by modified Rolink procedure. Spleen cells of parental donor mouse (C57BL’6) were injected to receptor murine F1 (BDF1) 3 times with interval of 6 days, followed by GVHR. Increased circulating immune complexes (CICs). Six kinds of Chinese prescriptions TSS, SGS, JTT, KHT, KNT, and KST are given orally to the