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目的:分析雾化吸入布地奈德治疗婴幼儿哮喘急性发作的多中心临床疗效。方法:选取我院2012年1月-2013年6月收治的96例婴幼儿哮喘急性发作患儿随机分为观察组和参考组,各48例。均给予两组患儿常规治疗,观察组采取雾化吸入布地奈德治疗,参考组采取地塞米松静脉雾化吸入,观察两组患儿的临床疗效。结果:观察组总有效率93.6%,参考组总有效率为81.3%,观察组临床疗效明显高于参考组(P<0.05)。观察组临床症状改善时间及住院时间明显少于参考组(P<0.05)。观察组不良反应发生率占2.1%,参考组不良反应发生率占12.5%,观察组不良反应发生率明显少于参考组(P<0.05)。结论:雾化吸入布地奈德治疗婴幼儿哮喘急性发作疗效显著,明显改善患儿临床症状,安全有效,可作为治疗哮喘急性发作的理想方法。
OBJECTIVE: To analyze the multicenter clinical efficacy of inhaled budesonide in the treatment of infant acute asthma attack. Methods: Ninety-six children with acute asthma exacerbated from infancy in our hospital from January 2012 to June 2013 were randomly divided into observation group and reference group, 48 cases each. Both groups were given routine treatment of children, the observation group to take inhalation of budesonide treatment, the reference group to take dexamethasone vein inhalation, the clinical efficacy of two groups were observed. Results: The total effective rate was 93.6% in the observation group and 81.3% in the reference group. The clinical efficacy of the observation group was significantly higher than that of the reference group (P <0.05). The clinical symptom improvement time and hospital stay in the observation group were significantly less than those in the reference group (P <0.05). The incidence of adverse reactions in the observation group was 2.1%, the incidence of adverse reactions in the reference group was 12.5%, and the incidence of adverse reactions in the observation group was significantly less than that in the reference group (P <0.05). Conclusion: Inhaled budesonide is effective in treating acute asthma in infants and young children. It can significantly improve the clinical symptoms of children and is safe and effective. It can be used as an ideal method for the treatment of acute asthma attacks.