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1983年和1984年6月至7月,卢旺达3岁以下儿童流行轮状病毒腹泻。本文作者于1985年4月在卢旺达农村对牛轮状病毒RIT4237株疫苗进行了试验。在双盲对照研究中,疫苗和安慰剂是通过2ml吸管口服给药。3～8月龄婴儿哺乳后立即给药。发热38℃以上或4周内接受口服脊髓灰质炎疫苗的婴儿不包括在试验内。
In 1983 and June-July 1984, rotavirus diarrhea was prevalent in children under 3 years of age in Rwanda. The authors tested the Bovine Rotavirus RIT4237 vaccine in rural Rwanda in April 1985. In a double-blind controlled study, the vaccine and placebo were administered orally through a 2 ml pipette. 3 to 8 months old infants immediately after feeding. Infants who developed fever above 38 ° C or oral polio vaccine within 4 weeks were not included in the trial.