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作者过去对温石棉经不同高温处理后的溶解度和细胞毒性问题,进行过试管内研究。本文目的在于观察对动物肺组织的致纤维化能力。选用生后四个月的雄性大白鼠,一组用加热685℃的温石棉,另一组用原温石棉,不加热。染尘方法采用气管一次注入10毫克粉尘。染尘后分别在4、8、12和16个月后各处死5只动物,通过肺内羟脯氨酸含量、二氧化硅含量和肺内温石棉尘滞留量的测定,以及组织切片,进行比较。实验结果:染尘后四个月,不加热组动物肺内羟脯氨酸含量为加热组的1.6倍。8、12、16个月后,两组动物的肺羟脯氨酸含量均有增加。16个月后,加热组为对照组的1.28倍,不加热组为对照组的1.68倍。全肺二氧化硅含量,4个月后加热组较对照组稍高,不加热组约为加热组
In the past, the authors conducted in vitro studies on the solubility and cytotoxicity of chrysotile treated with different high temperatures. The purpose of this article is to observe the ability to cause fibrosis in the lungs of animals. Selection of male rats four months after birth, a group with a temperature of 685 ℃ asbestos, the other group with asbestos, without heating. Dust method using tracheal injection of 10 mg of dust. Five animals were sacrificed after 4, 8, 12 and 16 months respectively after the exposure to dust. The contents of hydroxyproline in the lung, the content of silica and the determination of chrysotile dust retention in the lung and the tissue sections were performed Compare Experimental results: Four months after the dying, the content of hydroxyproline in the lung of the non-heated animals was 1.6 times that of the warm-up animals. After 8, 12 and 16 months, the contents of hydroxyproline in both groups increased. After 16 months, the heating group was 1.28 times that of the control group and 1.68 times that of the non-heating group. Whole lung silica content, 4 months after the heating group slightly higher than the control group, not heating group about the heating group