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目的 探讨应用银染核仁组成区 (AgNORs)计数定量作为非何杰金淋巴瘤 (NHL)鉴别诊断、病理分型、分级及预后指标的可能性。方法 用AgNORs计数定量方法分析6 8例NHL肿瘤组织的变化。结果 AgNORs计数低度NHL与中、高度NHL间差异有显著性 (P <0 0 5 ) ;但良性淋巴组织病变组与低度恶性NHL组间差异无显著性 (P >0 0 5 ) ,AgNORs均数值≤ 2 0 8组与 >2 0 8组 2组间生存曲线差异无显著性。结论 AgNORs计数有助于NHL的恶性度分级 ,无助于良恶性间鉴别诊断。以AgNORs计数均数2 0 8为界值分组 ,≤ 2 0 8组与 >2 0 8组二组预后无明显相关性。
Objective To investigate the possibility of using AgNORs counts as differential diagnosis, pathological typing, grading, and prognostic indicators for non-Hodgkin’s lymphoma (NHL). Methods AgNORs counting method was used to analyze the changes of 68 NHL tumor tissues. Results The difference of AgNORs between low-grade NHL and middle and high-level NHL was statistically significant (P < 0.05), but there was no significant difference between benign lymphoid disease group and low-grade NHL group (P > 0 05). AgNORs There were no significant differences in the survival curves between the two groups with mean values ≤ 28 and >08. Conclusion The AgNORs count contributes to the grade of malignancy of NHL and does not contribute to the differential diagnosis between benign and malignant. Counts of AgNORs were grouped by the mean value of 2 0 8 , and there was no significant correlation between the prognosis of patients in the ≤28 group and the >28 group.