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目的:观察托尼萘酸与阿托伐他汀联合复方丹参注射液治疗酒精性高脂血症综合征的疗效和安全性。方法:21例酒精性高脂血症综合征患者均给予维持酸碱平衡、吸氧等常规治疗,在此基础上,给予托尼萘酸片75 mg,口服,每日3次+阿托伐他汀钙片20 mg,口服,每日1次+复方丹参注射液4 ml,加入5%葡萄糖注射液150 ml中,静脉滴注,每日1次。疗程均为30 d。观察所有患者的临床疗效,治疗前及治疗6、12、18、24、30 d后的丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、总胆红素(TBIL)、总胆固醇(TC)、三酰甘油(TG)、红细胞计数(RBC)、血红蛋白(Hb)及不良反应发生情况。结果:患者经治疗后,总有效率为95.3%,不良反应发生率为28.5%。患者治疗6、12、18、24、30 d后的ALT、AST、TBIL及治疗12、18、24、30 d后的TC、TG均显著低于治疗前,且随时间延长逐渐降低,而治疗12、18、24、36 d后的RBC及治疗6、12、18、24、36 d后的Hb均显著高于治疗前,且随时间延长逐渐升高,差异均有统计学意义(P<0.05)。结论:托尼萘酸与阿托伐他汀联合复方丹参注射液治疗酒精性高脂血症综合征疗效显著,且安全性较好。
Objective: To observe the efficacy and safety of combination of tonic acid and atorvastatin with salvia miltiorrhiza in the treatment of alcoholic hyperlipidemia syndrome. Methods: Twenty-one patients with alcoholic hyperlipidemia syndrome were given conventional therapy such as acid-base balance and oxygen inhalation. On the basis of this, they were given 75 mg of tonic acid and orally, three times a day plus atorvastatin Calcium 20 mg, orally, once daily + compound Danshen injection 4 ml, add 5% glucose injection 150 ml, intravenous infusion, once daily. The course of treatment was 30 days. All the patients were observed for clinical efficacy, ALT, AST, TBIL (TBIL) ), Total cholesterol (TC), triglyceride (TG), red blood cell count (RBC), hemoglobin (Hb) and adverse reactions. Results: After treatment, the total effective rate was 95.3%, the incidence of adverse reactions was 28.5%. The levels of ALT, AST and TBIL at 6, 12, 18, 24 and 30 days after treatment were significantly lower than those before treatment and gradually decreased with time The RBC at 12, 18, 24 and 36 d and the Hb at 6, 12, 18, 24 and 36 d after treatment were significantly higher than before treatment and gradually increased with time (all P < 0.05). Conclusion: The combination of tonic acid and atorvastatin combined with Salvia Miltiorrhiza injection in the treatment of alcoholic hyperlipidemia syndrome has obvious curative effect and good safety.