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胃食管反流(gastroesophageal reflux,GER)常有食管下端括约肌(lower esophageal sphincter,LES)压力降低及胃排空延迟。作者用双盲法探讨灭吐灵治疗GER的原理并估价其疗效。方法19例男性病人,平均年龄50.7(26～74)岁,有12.7±7.7年的烧心和反胃史,经食管镜诊为反流性食管炎,排除其它可影响LES压力或胃排空的疾病、手术或服药史。在正式进入双盲试验前两周称基础期。逐日记录每例烧心和反胃的次数和持续时间及抗酸剂消耗量。并作食管镜检、食管粘膜抽吸活
Gastroesophageal reflux (GER) often has lower esophageal sphincter (LES) pressure and delayed gastric emptying. The authors used double-blind method to explore the principle of metoclopramide treatment of GER and evaluate its efficacy. Methods Nineteen male patients with an average age of 50.7 (26-74) years had a history of heartburn and nausea of 12.7 ± 7.7 years and were diagnosed as reflux esophagitis by esophagoscopy to exclude other diseases that could affect LES stress or gastric emptying , Surgery or medication history. In the formal entry into the double-blind test two weeks before the base period. Daily records of heartburn and nausea for each case the number and duration and antacid consumption. And for esophageal microscopy, esophageal mucosal suction live