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目的研究抑癌基因ING1的蛋白表达产物p33ING1在肺癌发生、发展中的作用。方法用免疫组化SP法检测p33ING1在40例肺癌和10例正常肺组织中的表达。结果p33ING1在肺癌组织中的阳性表达率(57.5%)明显低于正常肺组织(100.0%),P<0.05。p33ING1表达与淋巴结转移、TNM分期及组织分化有关。结论p33ING1低表达在肺癌的发生、发展中可能起重要作用;其对判断肺癌的恶性程度、浸润甚至转移有重要价值。
Objective To study the role of p33ING1, a protein of tumor suppressor gene ING1, in the development and progression of lung cancer. Methods The expression of p33ING1 in 40 lung cancer tissues and 10 normal lung tissues was detected by immunohistochemical SP method. Results The positive expression rate of p33ING1 in lung cancer tissues was significantly lower than that in normal lung tissues (57.5%, P <0.05). p33ING1 expression and lymph node metastasis, TNM stage and tissue differentiation related. Conclusion Low expression of p33ING1 may play an important role in the occurrence and development of lung cancer. It is of great value in judging the malignancy, infiltration and even metastasis of lung cancer.