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高尿酸血症可产生那些肾脏病变,如何诊断?高尿酸血症主要产生三种类型的肾损害:(1)慢性尿酸肾病,这和长期血中尿酸浓度增高有关,痛风的损害属于这一类型。病理表现为间质性肾炎,尿酸结晶沉积于肾髓质间质、乳头和锥体产生非特异性炎症反应。尿液检查有轻度蛋白尿及少量的红、白细胞。肾功能改变主要为浓缩功能丧失,以后逐渐发生肾功能不全。肾穿刺活检显示的肾组织内有双析光尿酸盐结晶具有诊断意义,但这种结晶主要在髓质,活检尚
Hyperuricemia can produce those kidney lesions, how to diagnose? Hyperuricemia mainly produces three types of kidney damage: (1) chronic uric acid nephropathy, which is associated with increased blood levels of uric acid in the long-term, gout damage belong to this type . Pathological manifestations of interstitial nephritis, uric acid crystals deposited in the medullary interstitial, nipple and cone non-specific inflammatory response. Urinalysis with mild proteinuria and a small amount of red and white blood cells. Renal changes mainly due to the loss of concentration, and subsequent progressive renal insufficiency. Kidney biopsy shows that there are biochemical analysis of bile acid uric acid crystals in the diagnosis of renal tissue, but this crystal is mainly in the medulla, biopsy