IgA肾病(IgAN)是世界范围内最常见的原发性肾小球疾病,约占我国原发性肾小球疾病的30%—40%,诊断后每10年约有20%患者进展到慢性肾功能衰竭。近年来,关于IgAN的小管间质损伤日益受到重视,多认为肾小管间质病变是反映IgAN肾功能下降严重程度和判断预后的重要指标,而且认为肾小管间质损害尤其是肾间质纤维化在IgAN进展中起重要作用,若无小管间质病变存在,即使 IgA nephropathy (IgAN) is the most common primary glomerular disease in the world, accounting for about 30% -40% of primary glomerular diseases in China. About 20% of patients progress to chronic Renal Failure. In recent years, the tubulointerstitial injury of IgAN has been paid more and more attention, and many think that tubulointerstitial lesions is a reflection of the severity of IgAN renal function and prognosis of an important indicator, and that tubulointerstitial damage especially renal interstitial fibrosis Plays an important role in the progression of IgAN, if no tubulointerstitial lesions exist, even though