对 1 2 2例起病年龄≥ 2 5岁 ,起病半年内无酮症的Ⅱ型糖尿病患者及 50例正常人用放射配体法进行谷氨酸脱羧酶抗体 (GAD65 Ab)、酪氨酸磷酸酶抗体 (IA2 Ab)的检测及胰岛功能测定。二种抗体在糖尿病组的阳性率分别为 2 1 3% ( 2 6/1 2 2 )及 5 7% ( 7/1 2 2 )。IA2 Ab的阳性率在糖尿病组与正常组无显著性差异 (P >0 0 5) ,且 7例阳性中仅 1例单独存在。结论 :在LADA的诊断中 ,酪氨酸磷酸酶的检测需与其它胰岛细胞自身抗体结合进行 112 cases of onset age ≥ 25 years old, within half a year onset of ketosis-free type II diabetes mellitus and 50 normal subjects using radioligand method for glutamic acid decarboxylase antibody (GAD65 Ab), tyrosine Detection of phosphatase antibody (IA2 Ab) and measurement of islet function. The positive rates of the two antibodies in diabetic group were 21.3% (2 6/1 2 2) and 5 7% (7/1 2 2), respectively. The positive rate of IA2 Ab was not significantly different between diabetic group and normal group (P> 0.05), and only one of 7 positive cases existed alone. Conclusion: In the diagnosis of LADA, the detection of tyrosine phosphatase needs to be combined with other islet cell autoantibodies