目的　观察海藻消瘿颗粒对丙基硫氧嘧啶致大鼠甲状腺肿模型的影响。方法　每日给大鼠灌服丙基硫氧嘧啶 (1.5mg/kg)连续造模 10d ,同时灌服海藻消瘿颗粒。 2 1d后处死 ,以甲状腺、垂体脏器系数和血清T3、T4 含量为指标 ,观察药物的作用。结果　海藻消瘿颗粒能明显抑制由丙基硫氧嘧啶所致的甲状腺肿大 ,但未见对血清T3、T4 含量的影响。结论　海藻消瘿颗粒具有较好的抗甲状腺肿作用 ,为临床应用及新药开发提供了一定的依据。 Objective To observe the effects of Haiza Xiaoxiao Granules on propylthiouracil-induced goiter model in rats. Methods Rats were fed with propylthiouracil (1.5mg/kg) daily for 10 days, and seaweed Xiaoyu granules were fed. 2 After 1d of sacrifice, the thyroid, pituitary organs coefficient and serum T3, T4 content were used as indicators to observe the effect of the drug. Results Seaweed Xiaoyu Granules could significantly inhibit the thyroid enlargement caused by propylthiouracil, but no effect on serum T3 and T4 levels was found. Conclusion Seaweed Xiaoyu granules have good anti-goitritis effect, which provides a basis for clinical application and development of new drugs.