细胞在繁殖时可能遇到各种各样的干扰 ,因此细胞需要用检查点时时监控基因组。当复制干扰发生时 ,复制检查点被激活并保证 M期在 S期完成后进行。检查点通过感受器 ,信号转导蛋白 ,效应器之间的一系列信号传导级联反应 ,作用于其最终调控对象 ,并排除“故障”。由于裂殖酵母同哺乳动物的检查点结构最为相似 ,文章将详细论述裂殖酵母复制检查点调控过程及其与人类检查点的相似之处。 Cells may encounter a variety of disturbances when they are bred, so cells need to constantly monitor the genome with checkpoints. When replication interference occurs, the replication checkpoint is activated and M phases are guaranteed after S phase is completed. The checkpoint acts on its final target of regulation through a series of signaling cascades between receptors, signal transducers, and effectors, and eliminates “faults.” Since fission yeast resembles the structure of mammalian checkpoints most closely, the article discusses in detail the regulatory process of fission yeast replication checkpoints and their similarities with human checkpoints.