病史摘要 李×,男,10月;患儿不规则发热半月,在当地应用抗生素(具体不详)无效。体检:T38.5℃.轻度贫血貌.两面颊有棕褐色色素沉着,其中有黄豆大小或点状白斑.两眼畏光.毛发呈银灰色.双侧颈部及两腋下淋巴结如蚕豆大小,心率160次,律齐,无杂音,双肺听(—),肝肋下5cm.脾肋下达盆腔.双下肢正常.神经系统未见异常;父,母均体健,无遗传病史及 Summary of medical history Li ×, male, October; children with irregular fever half a month, the local application of antibiotics (specific unknown) is invalid. Physical examination: T38.5 ℃ .A mild anemia appearance.Both cheeks have brown pigmentation, including the size of soybeans or punctate white spots.Both eyes photophobia hair was silver gray.Bilateral neck and two axillary lymph nodes such as broad beans Size, heart rate 160 times, law Qi, no noise, lung listening (-), liver ribs 5cm. Spleen ribs issued pelvic lower limbs normal. No abnormalities in the nervous system;