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取３００～４５０ｇ雄性大鼠１４只，随机分为两组，每组７只。Ⅰ组静脉注射１．０％硫贲妥钠３１．５ｍｇ／ｋｇ，Ⅱ组静脉注射１．０％异丙酚１２．５ｍｇ／ｋｇ，记录给药后不同时期ＨＲ、ＭＡＲ、±ｄｐ／ｄｔ变化。结果显示，给药后ＨＲ、ＭＡＰ、±ｄｐ／ｄｔ均较同组给药前明显降低，除给药后８ｍｉｎⅡ组ＭＡＰ较同时期Ⅰ组明显降低外，其它各时期、各观察指标两组间均无显著性差异。±ｄｐ／ｄｔ降低提示异丙酚与等效剂量硫贲妥钠对心肌收缩性有相同程度的抑制作用。
Take 300 ~ 450g male rats 14, were randomly divided into two groups of 7. Group Ⅰ received intravenous injection of 1.0% thiopental sodium 31.5 mg / kg, group Ⅱ intravenous injection of 1.0% propofol 12.5 mg / kg, and recorded changes of HR, MAR and ± dp / dt after administration . The results showed that the HR, MAP and ± dp / dt were significantly decreased after administration compared with the same group before administration, except that the MAP in group Ⅱ was significantly lower than that in group Ⅰ at 8min after administration, while in other periods, No significant difference. A decrease in ± dp / dt suggests that propofol and equivalent doses of thiopental sodium have the same degree of inhibition of myocardial contractility.