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黄连解毒汤煎剂及其石油醚和正丁醇萃取后的水层液，灌胃２０ ｇ·ｋｇ－１，对东莨菪碱致记忆获得障碍，ＮａＮＯ_２致记忆巩固障碍，乙醇致记忆再现障碍小鼠有显著改善作用；并能显著增加脑血流量，煎剂和萃取后的水层液，灌胃 １５ｇ·ｋｇ－１对脑缺血再灌注致记忆障碍小鼠有显著改善作用，灌胃１０ ｇ·ｋｇ－１对Ｄ－半乳糖致衰老小鼠的记忆障碍改善作用明显．
Decoction of Huanglian Jiedu Decoction and its aqueous solution extracted with petroleum ether and n-butanol were intragastrically administered with 20 g·kg-1, which resulted in obstacles to memory caused by scopolamine, and NaNO 2 caused memory consolidation failure. The mice with memory-reproducible impairment caused by ethanol were significantly Improve the effect; and can significantly increase cerebral blood flow, decoction and extracted aqueous layer fluid, intragastric administration of 15g · kg-1 significant improvement of cerebral ischemia reperfusion memory impairment in mice, gavage 10 g · kg -1 can significantly improve the memory impairment induced by D-galactose in aging mice.