论文部分内容阅读
目的评价海南岛百岁老人幽门螺杆菌(H·pylori)感染的流行病学及影响因素。方法采用整群随机抽样的方法,问卷调查了海南岛不同地区(东部、中部、南部的农村、城区、沿海和山区)100岁以上老人316例,并随机普查同一地区90～95岁老人426例作为对照组。对受检者根据有无消化道症状分为健康组,症状组和对照组,分别进行C14尿素呼气试验、免疫印迹法测定血清Hp-IgG抗体及IgA、IgG、C3、C4;所有资料进行χ2检验及分析。结果百岁老年人群总的H·pylori感染率为84.5%;山区高于沿海(91.3%vs57.7%,P<0.01),城区低于农村(33.3%vs71.4%,P<0.01),农民和胃病史者Hpylori感染率高于市民和无胃病者(74%vs48.3%,P<0.05;96.7%vs59.8%,P<0.01);饮河水者H·pylori感染率高于饮井水者(88.6%vs69.7%,P<0.05)常喝椰子水及吃槟榔者H·pylori感染率低于饮冷水及不吃槟榔者(37.9%vs62.1%,P<0.01)症状组高于健康组和对照组(88.7%vs84.8%,59.1%,P<0.01)三组之间C3、C4也存在显著差异(χ2=0.139,P=0.046)。结论H·pylori在海南省百岁老年人群中存在较高的感染率,并且与地区、职业、饮食习惯、环境因素、免疫功能及病史有关。
Objective To evaluate the epidemiology and influencing factors of H. pylori infection in centenarians in Hainan Island. Methods A total of 316 cases of elderly over 100 years old in different areas of Hainan Island (rural areas, urban areas, coastal areas and mountainous areas) of Hainan Island were surveyed by cluster random sampling method. Randomly surveyed 426 cases of 90-95-year-olds in the same area As a control group. The subjects were divided into healthy group, symptom group and control group according to the presence or absence of gastrointestinal symptoms, respectively, C14 urea breath test, serum Hp-IgG antibody and IgA, IgG, C3, C4 were determined by Western blotting; χ2 test and analysis. Results The prevalence of H. pylori infection was 84.5% in the centenarians, higher in the mountainous areas than in the coastal areas (91.3% vs57.7%, P <0.01), in the urban areas was lower than in the rural areas (33.3% vs71.4%, P <0.01) The prevalence of Hpylori infection among peasants and patients with gastric history was higher than that of citizens and no-stomach disease (74% vs48.3%, P <0.05; 96.7% vs59.8%, P <0.01) The prevalence of H · pylori in those who drank coconut water and betel nuts was lower than that in drinking water and no-betel nuts (88.6% vs69.7%, P <0.05) (88.7% vs84.8%, 59.1%, P <0.01). There were also significant differences in C3 and C4 between the three groups (χ2 = 0.139, P = 0.046). Conclusion H · pylori has a high infection rate in the centenarian population in Hainan Province, and is related to the region, occupation, dietary habits, environmental factors, immune function and medical history.