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[国外的甲磺酰派姆(P2S)同国内的氯化派姆(商品名氯磷定)和碘化派姆(商品名解磷定)一样,广泛地用于治疗有机磷酸酯抗胆碱酯酶剂中毒,因在严重中毒时静脉注射急救使用不方便,故一般都采用肌肉注射。国外此类药物除用于治疗外,还作预防用——译者]。本研究的目的是确定P2S肌肉注射的治疗剂量及观察其临床副作用。实验志愿受试者均为健康男性军人,年龄在18～26岁之间。实验分两大组:第一组受试者单独分别肌肉给1、2和3次各500 mg的P2S;第二组每人先口服4.0 g(每次1 g,共服4次)的P2S,然后同样分别再肌肉注射给1、2和3次500 mg的P2S。以上受试者在规定时间内静脉采血测定血浆中P2S的浓度,并观察其临床副作用。
[Foreign methanesulfonyl pyrazole (P2S) is widely used for the treatment of organophosphate ester anticholinergic, like chlorpyrifos and chlorpyrifos iodide (trade name Phosphatidylinositol) Esterase poisoning, intravenous injection in the case of severe poisoning inconvenient use, it is generally used intramuscular injection. In addition to the treatment of such drugs abroad, but also for the prevention - translator]. The purpose of this study was to determine the therapeutic dose of P2S intramuscular injection and to observe its clinical side effects. Experimental volunteers were healthy male soldiers, aged 18 to 26 years old. Two groups were divided into two groups: the first group received 500 mg of P2S once, twice, and three times respectively for the muscle of the first group; the second group each received 4.0 g (1 g for 4 times) , Followed by the same intramuscular injection of 1, 2 and 3 500 mg P2S respectively. The above subjects were venous blood within the specified time to determine the concentration of plasma P2S, and observe the clinical side effects.