【摘 要】
：
Tumorigenesis involves metabolic reprogramming and abnormal lipid metabolism,which is manifested by increased endogenous fat mobilization,hypertriglyceridemia,and increased fatty acid synthesis.Fatty acid synthase(FASN)is a key enzyme for the de novo synt
【机 构】
：
Tianjin Medical University Cancer Institute and Hospital,National Clinical Research Center for Cance
论文部分内容阅读
Tumorigenesis involves metabolic reprogramming and abnormal lipid metabolism,which is manifested by increased endogenous fat mobilization,hypertriglyceridemia,and increased fatty acid synthesis.Fatty acid synthase(FASN)is a key enzyme for the de novo synthesis of fatty acids,and monoacylglycerol esterase(MGLL)is an important metabolic enzyme that converts triglycerides into free fatty acids.Both enzymes play an important role in lipid metabolism and are associated with tumor-related signaling pathways,the most common of which is the PI3K-AKT signaling pathway.They can also regulate the immune microenvironment,participate in epithelial-mesenchymal transition,and then regulate tumor invasion and metastasis.Current literature have shown that these two genes are abnormally expressed in many types of tumors and are highly correlated with tumor migration and invasion.This article introduces the structures and functions of FASN and MGLL,their relationship with abnormal lipid metabolism,and the mechanism of the regulation of tumor invasion and metastasis and reviews the research progress of the relationship of FASN and MGLL with tumor invasion and metastasis.
其他文献
The accelerating effect of natural convection on the melting of phase change material(PCM)has been extensively demonstrated.However,such an influence is directly dependent on the size and shape of domain in which phase change happens,and how to quantitati
目的 探讨缺血性脑卒中患者危险程度的影响因素.方法 选取2018年以来在桂林市人民医院神经内科经头颅CT和(或)MRI确诊的缺血性脑卒中患者877例,通过问卷调查收集研究对象的基本信息、流行病学信息及临床资料,将研究对象按照其缺血性脑卒中危险评级分为低危组(349例)、中危组(243例)、高危组(285例).分析不同性别、年龄缺血性脑卒中患者相关危险因素的暴露水平,并对缺血性脑卒中的危险因素进行单因素分析,将单因素分析中有统计学意义的危险因素进行logistic回归分析.结果 本研究中高危缺血性脑卒中的检
微生物发酵是一种经济高效、可持续的生产方式,可替代植物种植和化学合成来生产多种植物来源的药物.苄基异喹啉类生物碱作为植物来源生物碱的典型代表,具有多种重要的生理活性,已成为极具吸引力的微生物合成研究的靶标分子.随着该类生物碱天然生物合成途径逐渐被阐明以及多种酶学元件的发现,使得通过大肠杆菌和酿酒酵母等微生物宿主合成苄基异喹啉类生物碱的研究取得了重大进展.本综述着重介绍了这些进展中的突破性成果,包括苄基异喹啉类生物碱微生物合成过程中瓶颈反应的突破以及合成途径中相关酶的催化特性对代谢流的影响等,指出了微生物生
The realization of protein functional movement is usually accompanied by specific conformational changes,and there exist some key residues that mediate and control the functional motions of proteins in the allosteric process.In the present work,the pertur
睡眠障碍是脑卒中患者最常见并发症之一,影响患者的睡眠质量和预后.被动式音乐疗法具有安全、舒适、有效的特点,已被应用于脑卒中后睡眠障碍(PSSD),但其作用机制尚未完全清楚.被动式音乐疗法的干预方式主要包括单一被动式音乐、联合被动式音乐的二联及三联综合疗法.在改善睡眠质量方面,联合被动式音乐的二联疗法优于单一疗法,提示被动式音乐与其他疗法可能存在协同作用.
目的 探讨饮用油茶与糖尿病患病风险的关联.方法 选取广西社区人群13 422例为研究对象,其中2 046例来自饮用油茶地区的广西桂林市和恭城县社区人群,11 376例来自不饮用油茶地区的广西南宁市、玉林市健康体检人群.采用结构化问卷,调查研究对象的饮用油茶史、吸烟、饮酒、运动、近12个月饮食频率等信息.测量并收集血压、体质量指数(BMI)、血糖、血脂结果,统计饮用油茶人群中糖尿病、糖尿病前期患病情况.通过匹配的病例对照研究,按照性别年龄匹配纳入病例和对照进行分析.使用条件logistic回归模型评估饮用油
Although lead-based perovskite solar cells have achieved more than 25％power conversion efficiency,the toxicity of lead and instability are still urgent problems faced in industrial application.Lead-free halide double perovskite(DP)materials are promising
目的 了解我国中医传统功法治疗膝骨性关节炎(KOA)的研究现状及热点.方法 运用CiteSpace软件对CNKI收录的中医传统功法治疗KOA的相关文献的作者、研究机构及关键词进行可视化分析.结果 共纳入65篇文献,发文量最多的作者和研究机构分别是仲卫红(4篇)和福建中医药大学(13篇).绘制了作者合作网络图谱、研究机构合作网络图谱、关键词共现网络图谱和关键词聚类的时间视图,共得到4个聚类.结论 中医传统功法治疗KOA领域发展速度缓慢,存在作者与研究机构合作意识薄弱、研究类型单一、研究地域差异等不足.太极拳
Bone and teeth are hard tissues.Hard tissue diseases have a serious effect on human survival and quality of life.Primary cilia are protrusions on the surfaces of cells.As antennas,they are distributed on the membrane surfaces of almost all mammalian cell
目的 探讨超声引导右美托咪定复合罗哌卡因髂筋膜阻滞(FICB)在老年患者全髋关节置换术(THA)围术期的镇痛效果.方法 选取我院2020年1月—2021年6月因股骨颈骨折行THA患者60例,根据随机数字表法将其分为观察组与对照组,各30例.蛛网膜下腔麻醉前应用“领结征”法行超声引导FICB,对照组给予0.3％罗哌卡因40 mL,观察组给予1 μg/Kg右美托咪定+0.3％罗哌卡因混合液共40 mL.记录FICB起效时间;记录蛛网膜下腔穿刺时(T1)、术后6 h(T2)、术后12 h(T3)、术后24 h(