论文部分内容阅读
目的】 探讨孕期饮酒致髓鞘发育异常机制。【方法】 以3H TdR掺入体外培养少突胶质细胞作为细胞增殖指标。观察酒精及其代谢产物乙醛对细胞增殖的影响。【结果】 体外处理 2 4h和 48h后 ,绝大多数剂量组CPM值均低于相应时间的对照组 (P <0 0 5 ) ,且随酒精、乙醛浓度增加 ,细胞增殖能力显著下降 ,存在剂量反应关系。CPM值与实验剂量呈明显负相关。【结论】 酒精、乙醛对少突胶质细胞生长有明显抑制作用。酒精及其代谢产物乙醛可推迟细胞增殖和诱发细胞异常变化 ,这可能是胎儿酒精综合征中的髓鞘发育异常的主要原因之一。
Objective] To investigate the mechanism of drinking myelodysplasia during pregnancy. 【Method】 3HddR was used to culture oligodendrocytes in vitro as a cell proliferation index. The effects of alcohol and its metabolite acetaldehyde on cell proliferation were observed. 【Results】 CPM values in the vast majority of the dosage groups were significantly lower than those of the control group (P <0.05) after 24 and 48 hours of in vitro treatment, and the cell proliferation ability was significantly decreased with the increase of alcohol and acetaldehyde levels Dose response relationship. The CPM value was negatively correlated with the experimental dose. 【Conclusion】 Alcohol and acetaldehyde can significantly inhibit the growth of oligodendrocytes. Alcohol and its metabolite acetaldehyde can delay cell proliferation and induce abnormal cell changes, which may be one of the main causes of myelodysplasia in fetal alcohol syndrome.