应用非特异性免疫佐剂厌氧棒状杆菌菌苗(CP)对122例恶性胸水病人进行治疗,使大量胸水迅速控制和消退,并末见有复发,有效率达94.3%。病人生存期延长平均为11.4月,与对照组比较有非常显著意义。20例病人注射CP24小时后癌细胞的超微结构发生明显变化。应用[~3H]-TdR和[~3H]-UR掺入法,发现CP对K562细胞有直接毒性作用.提示CP对恶性胸水抗癌活性有直接作用。 The non-specific immune adjuvant C. anaerobic bacillus anaerobe (CP) was used to treat 122 patients with malignant pleural effusion, which resulted in the rapid control and regression of large amounts of pleural fluid. At the end of the treatment, there was a recurrence with an effective rate of 94.3%. The average survival time of patients was 11.4 months, which was very significant compared with the control group. The ultrastructure of cancer cells changed significantly after injection of CP for 24 hours in 20 patients. Using [~3H]-TdR and [~3H]-UR incorporation methods, it was found that CP has direct toxic effects on K562 cells, suggesting that CP has a direct effect on the anticancer activity of malignant pleural effusion.