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子痫前期性心脏病是在重度子痫前期的病理基础上发生的心功能衰竭和心肌损害,对母婴危害很大。血管紧张素Ⅱ1型受体(AT1R)基因多态性与子痫前期及心脏病关系密切,AT1R表达异常将导致子痫前期的发生发展,从而增加心血管疾病的危险性。AT1R基因多态性表现种族和性别差异性,如果能确定两者相关,可将其作为子痫前期性心脏病病情预测和监测的新指标,有助于对子痫前期性心脏病患者的预后做出评估。就其在子痫前期及心脏病发病中的作用和机制作一综述,进一步阐述其与子痫前期性心脏病的相关性。
Pre-eclampsia is a heart failure and myocardial damage that occurs on the basis of the pathology of severe preeclampsia and is very harmful to mothers and infants. The polymorphism of angiotensin Ⅱ type 1 receptor (AT1R) is closely related to preeclampsia and heart disease. The abnormal expression of AT1R will lead to the development of preeclampsia and increase the risk of cardiovascular diseases. AT1R gene polymorphism shows race and gender differences, if we can determine the correlation between the two can be used as a new indicator of the prognosis and monitoring of preeclampsia heart disease, contribute to the prognosis of patients with preeclampsia heart disease Make an assessment To review its role and mechanism in the pathogenesis of preeclampsia and heart disease and to further elucidate its correlation with preeclampsia heart disease.