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The platinum (II) complexes of the [Pt (N4,N7-Ribavirin) (DMSO) Cl], [Pt (N4,N7-De-oxyribavirin) (DMSO) Cl] were obtained by the reactions of cis-[Pt (DMSO)2 Cl2] and K[Pt (DMSO) Cl3] with 1-??-D-ribofuranosyl-1,2,4-triazole-3-carboxamide (Ribavirin) and its deoxy-analogue (deoxyribavirin). The preparation of 1-(2’-deoxy-?-D-ribofuranosyl) -1,2,4-triazole-3-carboxamide was also performed through a four-step procedure, protection of 3’, 5’-dihydroxyl group of Ribavirin with 1,3-dichloro-1,1,3,3-tetraisopropyldisiloxane (TPDS-Cl), phenoxythio-carbonylation of the 2’-hydroxyl group of 3’, 5’-O-TPDS-Ribavirin with phenoxythiocarbonyl-chloride (PTC-Cl), reduction of 2′-O-phenoxythiocarbonyl ester of 3’, 5’-O-TPDS-Ribavirin with tri-n-butyltin hydride and AIBN, deprotection of 3’, 5’-O-TPDS-Ribavirin with tetrabutylammon-ium fluoride in THF.
The platinum (II) complexes of the [Pt (N4, N7-Ribavirin) (DMSO) Cl], [Pt (N4, N7- Deoxy oxybavirin) (DMSO) DMSO) 2 Cl2] and K [Pt (DMSO) Cl3] with 1 -? - D-ribofuranosyl-1,2,4-triazole- 3-carboxamide (Ribavirin) and its deoxy-analogue (deoxyribavirin) 1- (2’-deoxy-? - D-ribofuranosyl) -1,2,4-triazole-3-carboxamide was also performed through a four-step procedure, protection of 3 ’, 5’-dihydroxyl group of Ribavirin with 1 , 3-dichloro-1,1,3,3-tetraisopropyldisiloxane (TPDS-Cl), phenoxythio-carbonylation of the 2’-hydroxyl group of 3 ’, 5’-O-TPDS-Ribavirin with phenoxythiocarbonyl-chloride ), reduction of 2’-O-phenoxythiocarbonyl ester of 3 ’, 5’-O-TPDS-Ribavirin with tri-n-butyltin hydride and AIBN, deprotection of 3’, 5’-O-TPDS- Ribavirin with tetrabutylammon-ium fluoride in THF.