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用改良的ELISA检测25例正常对照组和32例急性脑血管病患者的血清和脑脊液(CSF)中的脑型肌酸激酶同功酶BB(creatine kinase isoenzyme BB)浓度。32例急性脑血管病患者CSF CKBB平均水平为16.62±8.3ng/ml,明显高于对照组(7.5—4.8ng/ml)。发病24h内CSFCKBB轻微增高,24～48h达高峰,以后下降,7天左右尚未恢复正常。病初CSF CKBB水平明显高于恢复期。9例高血压性脑出血的血肿出血量(按CT片上血肿大小计算)与患者CSF CKBB有密切关系(r=0.8127,P<0.01)。血肿体积(X)与CSF CKBB浓度(y)的回归方程y—7.945±0.872X。
The concentration of creatine kinase isoenzyme BB in serum and cerebrospinal fluid (CSF) of 25 normal controls and 32 patients with acute cerebrovascular disease was detected by modified ELISA. The average level of CSF CKBB in 32 patients with acute cerebrovascular disease was 16.62 ± 8.3ng / ml, which was significantly higher than that of the control group (7.5-4.8ng / ml). Within 24 hours of onset, CSFCKBB slightly increased, peaked at 24-48 hours, then decreased and remained normal after about 7 days. Early onset of CSF CKBB was significantly higher than recovery. Hemorrhage volume of 9 cases of hypertensive intracerebral hemorrhage (calculated on the basis of CT hematoma size) was closely related to CSF CKBB (r = 0.8127, P <0.01). The regression equation of hematoma volume (X) and CSF CKBB concentration (y) y-7.945 ± 0.872X.