Mouse-adapted SARS-CoV-2 replicates efficiently in the upper and lower respiratory tract of BALB/c a

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Dear Editor,rnAs of June,2020,more than ten million cases of COVID-19 have been reported worldwide.The causative pathogen of the disease is a novel coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (World Health Organization,2020).Animal infection models are important to characterize the infection,pathogenesis,and immunology of SARS-CoV-2,as well as for the development of medications and vaccines against COVID-19.Mice are particularly attractive animal models for their identical genetic background,reliable reproducibility,well characterized biology,and the huge availability of research reagentsand knockout animals.
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