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目的：测定氯霉素氢化可的松滴耳剂中二组份的含量。方法：采用新Ｖｉｅｒｏｒｄｔ法不经分离直接测定氯霉素氢化可的松滴耳剂中氯霉素、氢化可的松的含量。结果：２７８，２４８ｎｍ分别为测定波长，以稀醇为空白，氯霉素和氢化可的松的平均回收率及ＲＳＤ分别为１００．７９％、０．４２％；９９．８２％、１．４２％。结论：氯霉素氢化可的松滴耳剂以稀醇为稀释剂，不经分离，直接在２４８，２７８ｎｍ处测其吸收值，α与β乘积小于０．５；Ａａ＋ｂ２７８与βＡａ＋ｂ２４８、Ａａ＋ｂ２４８与αＡａ＋ｂ２７８的比值均大于１．２，符合新Ｖｉｅｒｏｒｄｔ法的要求，本法操作简便快速，重现性好，可消除二组份相互干扰，结果满意
Objective: To determine the content of two components in chloramphenicol hydrocortisone ear drops. Methods: The new Vierordt method was used to directly determine the content of chloramphenicol and hydrocortisone in chloramphenicol hydrocortisone ear drops without separation. Results: The average recoveries and RSDs of chloramphenicol and hydrocortisone were 100.79%, 0.42%, 99.82%, 1.42 %. Conclusion: The chloramphenicol hydrocortisone ear drops dilute alcohol as diluent, without separation, directly measured at 248,278 nm absorbance, α and β product is less than 0.5; Aa + b278 and βAa + b248, Aa + b248 and αAa + b278 Of the ratio are greater than 1.2, in line with the requirements of the new Vierordt method, the method is simple and rapid operation, good reproducibility, can eliminate the two components interfere with each other, with satisfactory results