目的:静脉注射丙种球蛋白(IV IG)治疗极低体重儿重症感染的临床疗效和治疗前后患儿血清IgG水平的变化。方法:将34例重症感染的极低体重儿随机分成IV IG组及对照组,原则都选用同类敏感抗生素,前者加用IV IG,所有病例均在入院后立即和用药后1周检测血清IgG水平的变化,并观察临床疗效。结果:IV IG组治疗1周后IgG中水平明显升高(P<0.01),而对照组无明显变化,两组治疗前后差异有统计学意义(P<0.01),IV IG组疗效明显优于对照组。结论:极低体重儿重症感染时IV IG治疗临床疗效显著。 Objective: To evaluate the clinical efficacy of intravenous gammaglobulin (IVIG) in the treatment of severe infectious diseases of very low birth weight infants and the changes of serum IgG levels in children before and after treatment. Methods: 34 cases of severe low birth weight infants were randomly divided into IVIG group and control group. In principle, similar sensitive antibiotics were used. The former was given IVIG. All cases were tested for serum IgG immediately after admission and 1 week after treatment Changes, and observe the clinical efficacy. Results: After 1 week of treatment, the level of IgG in IVIG group was significantly increased (P <0.01), but there was no significant change in control group. There was significant difference between the two groups before and after treatment (P <0.01) Control group. Conclusion: The clinical efficacy of IV IG in severe low birth weight infants is significant.