Objective. Preoperative differentiation of primary andmetastatic ovarian tumors is difficult. Young age of the patient,bilateralism and reduced multilocularity are cited characteristics of secondary ovarian malignancies. We sought to identity pre- and perioperative factors which may aid in differentiating metastatic ovarian tumors from primary ovarian malignancies.Patients and methods. We performed a retrospective analysis of demographic parameters, preoperative serum tumor marker levels and ultrasonographic as well as operative findings in 38 patients with secondary ovarian malignancies and 76 control patients with primary epithelial ovarian cancer. All patients were treated at our institute from 1996 to 2003. Results. The proportion of secondary ovarian tumors, of all ovarian malignancies,was 5.2% . The most common sites of origin were the gastrointestinal tract (42% ), breast (29% ) and peritoneum(16% ). Fifty- eight percent of the patients with a secondary ovarian tumor had a history of previous malignancy; 42% of the primary malignancies were detected only following diagnosis of ovarian metastasis. The two patient groups (primary or secondary ovarian malignancy) could not be distinguished by age, parity, menopausal status or history of hysterectomy.Of the serum markers, the preoperative level of serum CA 125 was not different between the two groups. Both serum tumor associated trypsin inhibitor (TATI) (7.2 ± 9.6 vs. 4.7 ± 9.4μ g/l [mean ± SD]) and carsino embryonic antigen (CEA) levels(19.7± 30.8 vs. 6.7 ± 120.0 μ g/l) were higher in the group with secondary malignancies (P < 0.02). The metastatic ovarian tumors, as measured preoperatively by ultrasonography (US),were smaller (64 mm, 62- 89 mm [median, 95% Cl]) than the primary tumors (105 mm, 104- 134 mm) (P < 0.0005). The same was true for tumor sizes measured at surgery (P < 0.05)- . Furthermore, the secondary tumors were more often solid(50 vs. 10% ) (P < 0.005), and more seldom cystic- solid (17 vs. 55% ) (P < 0.001). Presence of ascites was more common among patients with primary ovarian malignancies in both preoperative US (P < 0.01) and at operation (P < 0.0001)- . Bilateralism, presence of adhesions, and carcinosis did not differ between the two groups. Conclusions. When evaluating a patient with an ovarian tumor, a history of malignancy strongly suggests a metastatic nature. Size less than 9 cm, solid structure, absence of ascites and elevated serum CEA and TATI levels were typical features associated with secondary ovarian malignancies. Objective. Preoperative differentiation of primary and metastatic ovarian tumors is difficult. Young age of the patient, bilateralism and reduced multilocularity are promoted characteristics of secondary ovarian malignancies. We sought to identity pre- and perioperative factors which may aid in differentiating metastatic ovarian tumors from primary ovarian malignancies. Patients and methods. We performed a retrospective analysis of demographic parameters, preoperative serum tumor marker levels and ultrasonographic as well as operative findings in 38 patients with secondary ovarian malignancies and 76 control patients with primary epithelial ovarian cancer. All patients were treated at our institute from 1996 to 2003. Results. The proportion of secondary ovarian tumors, of all ovarian malignancies, was 5.2%. The most common sites of origin were the gastrointestinal tract (42%), breast (29%) and peritoneum (16%) Fifty- eight percent of the patients with a secondary ovarian tumor had a histo The two patient groups (primary or secondary ovarian malignancy) could not be distinguished by age, parity, menopausal status or history of hysterectomy. Of the serum markers, the preoperative level of serum CA 125 were different between the two groups. Both serum tumor associated trypsin inhibitor (TATI) (7.2 ± 9.6 vs. 4.7 ± 9.4 μg / l [mean ± SD]) and carsino embryonic antigen ( (P <0.02). The metastatic ovarian tumors, as measured preoperatively by ultrasonography (US), were smaller (64 mm , 62-89 mm [median, 95% Cl]) than the primary tumors (105 mm, 104-134 mm) (P <0.0005) , the secondary tumors were more often solid (50 vs. 10%) (P <0.005), and more seldom cystic-solid (17 vs. 55%)Presence of ascites was more common among patients with primary ovarian malignancies in both preoperative US (P <0.01) and at operation (P <0.0001) -. Bilateralism, presence of adhesions, and carcinosis did not differ between the two groups. Conclusions. When evaluating a patient with an ovarian tumor, a history of malignancy strongly suggests a metastatic nature. Size less than 9 cm, solid structure, absence of ascites and elevated serum CEA and TATI levels were typical features associated with secondary ovarian malignancies.