目的　研究在脉冲噪声环境下药物R N6 phenylisopropyladenosine (R PIA)对听觉系统损伤的预防作用。方法　 6只美洲灰鼠 (chinchillas)在暴露于 10 0个 15 0dB (peak ,SPL)脉冲噪声前 2小时在其右耳用药 (R PIA)(0 1mmol/L 30 μl)。脉冲噪声是模拟M 16来福枪而成。 结果　用R PIA药物的右耳其暂时性阈移 (TTS)和永久性阈移 (PTS)比不用药以及仅用生理盐水的左耳少〔10～ 2 0 (dB)〕。其用药右耳的毛细胞缺失率明显比左耳少。结论　R PIA可有效地预防听觉系统遭受脉冲噪声危害 Objective To study the preventive effect of R N6 phenylisopropyladenosine (R PIA) on auditory system injury in impulsive noise environment. Methods Six chinchillas were exposed to R PIA (0 1 mmol / L, 30 μl) 2 hours before exposure to 10 0 pulses of SPL (pulse width at 25 ° C). Impulse noise is simulated M 16 rifle made. Results In the right ear of RIA PIA drugs, their transient threshold shift (TTS) and permanent threshold shift (PTS) were less than [10 to 20 (dB)] in the right ear with saline alone and with saline alone. The loss of hair cells in the right ear was less than that in the left ear. Conclusion R PIA can effectively prevent the auditory system from impulse noise damage