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目的 :了解肝硬化与胃液体排空障碍的关系。方法 :采用实时超声胃窦面积法测定了 2 6例肝硬化患者和 14例健康人的胃液体排空 ,同时用放射免疫法检测了空腹血胃动素和胃泌素水平。结果 :肝硬化组胃液体半排空时间(GET1/ 2 )为 (34.5 3± 8.2 3) m in,较正常对照组 (2 8.0 6± 4.11) min明显延迟 (P<0 .0 1) ,表明肝硬化患者存在明显的胃液体排空障碍。肝硬化患者 GET1/ 2与上消化道症状积分呈正相关 (r=0 .42 6 ,P<0 .0 5 ) ,表明肝硬化患者的胃动力障碍是引起上消化道症状的重要原因 ;肝硬化患者 GET1/ 2与肝功能受损程度呈正相关 (r=0 .491,P<0 .0 5 ) ;肝硬化组血浆胃动素浓度为 (4 18.5 4± 5 4.6 3) ng/ L,血清胃泌素浓度为 (87.73± 2 4.37) ng/ L,均较正常对照组增高 (P均 <0 .0 1)。结论 :肝硬化患者胃液体排空障碍可能与肝功能受损、胃肠激素代谢异常有关。
Objective: To understand the relationship between liver cirrhosis and gastric emptying disorder. Methods: Gastric fluid emptying was measured in 26 patients with cirrhosis and 14 healthy individuals by real-time gastric antrum area method. Fasting motilin and gastrin levels were measured by radioimmunoassay. Results: The gastric emptying time (GET1 / 2) of cirrhosis group was (34.5 3 ± 8.23) mins, significantly delayed than that of the normal control group (28.0 ± 4.11) min (P <0.01) Show that there is a significant gastric emptying disorder in patients with cirrhosis. There was a positive correlation between GET1 / 2 and upper gastrointestinal symptom scores in patients with cirrhosis (r = 0.42 6, P <0.05), indicating that gastric motility disorders in patients with cirrhosis are the major causes of upper gastrointestinal symptoms; cirrhosis There was a positive correlation between GET1 / 2 and impaired liver function (r = 0.491, P <0.05). Plasma motilin level in cirrhosis group was (4 18.54 ± 5 4.6 3) ng / L, serum The concentration of gastrin was (87.73 ± 2.43) ng / L, both higher than the normal control group (all P <0.01). Conclusion: Gastric fluid emptying disorder in patients with cirrhosis may be related to impaired liver function and gastrointestinal hormone metabolism.