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血透(HD)治疗的尿毒症患者,血浆血管活性激素(VAH)如心房利钠肽(ANP),肾素活性(PRA)和内皮素(ET)常升高。本文旨在对连续非卧床腹透(CAPD)患者的VAH浓度及其有关的血液动力学指标之间的关系进行研究。终末期肾衰(ESRF)患者17例,男性5例,女性12例。除1例外,年会均大于18岁(13～62岁,平均38.5)。肾衰病因包括慢性肾小球肾炎14例,狼疮性肾炎、多囊肾、糖尿病肾病各1例。患者作CAPD至少12个月,血液动力学稳定。在本研究前2个月以及研究期间所用药物(包括降压药)、透折方法和透折液均无变动,且不予输血,干体重保持不变。分别于开始时,第6和12周用放免法测定血浆ANP·ET和PRA,并于早晨令患者平卧1小时,腹
Patients with uremia treated with hemodialysis (HD) often have elevated levels of plasma vasoactive hormones (VAH) such as atrial natriuretic peptide (ANP), renin activity (PRA) and endothelin (ET). This article aims to investigate the relationship between VAH concentration and its associated hemodynamic parameters in patients with continuous ambulatory peritoneal dialysis (CAPD). There were 17 patients with end-stage renal failure (ESRF), 5 males and 12 females. With one exception, the annual sessions were greater than 18 years (13 to 62 years, mean 38.5). Causes of renal failure include chronic glomerulonephritis in 14 cases, lupus nephritis, polycystic kidney disease, diabetic nephropathy in 1 case. Patients with CAPD for at least 12 months, hemodynamically stable. During the first two months of the study and during the study period, the drugs used (including antihypertensive drugs), permeation methods and permeation were unchanged and blood transfusions were performed without any loss of dry weight. Plasma ANP · ET and PRA were measured by radioimmunoassay at the beginning, 6 and 12 weeks respectively, and in the morning patients were left lying for 1 hour and their abdomen