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目的了解某院肾移植住院患者免疫抑制剂的使用情况,为寻找更有效的免疫抑制剂治疗方案以促进临床合理用药并提高肾移植患者的生存质量提供依据。方法回顾性查阅某院2015年肾脏移植病历74份,记录患者住院期间原发疾病、肾移植术后并发症和排斥反应、用药情况和住院费用等信息,并对患者免疫抑制剂的使用情况进行分析。结果患者的平均年龄为(42.51±12.18)a;平均住院日为(25.95±13.63)d;平均总药费约为45 617.91元;免疫抑制剂平均费用为21 737.73元,占平均总药费的47.65%;免疫抑制剂使用频率排序前3位的品种分别为糖皮质激素、吗替麦考酚酯、环孢素A。结论肾移植住院患者免疫抑制剂费用占比较大,且多为联合用药,寻找更有效、不良反应更少、价格更低的免疫抑制治疗方案对提高肾移植患者的生存质量和挽救更多肾功能衰竭患者的生命具有重要意义。
Objective To understand the use of immunosuppressive agents in inpatients with renal transplantation in a hospital and to provide evidences for finding more effective immunosuppressant regimens in order to promote clinical rational use of drugs and improve the quality of life of renal transplant recipients. Methods A retrospective review of 74 cases of renal transplant records in a hospital in 2015, records of patients with primary disease during hospitalization, complications and rejection after renal transplantation, drug use and hospitalization costs and other information, and the use of patients with immunosuppressive agents analysis. Results The average age of patients was (42.51 ± 12.18) years. The average length of stay was (25.95 ± 13.63) days. The average total cost was 45 617.91 yuan. The average cost of immunosuppressants was 21 737.73 yuan, 47.65%. The first three kinds of immunosuppressants were glucocorticoid, mycophenolate mofetil and cyclosporin A respectively. Conclusion In hospitalized patients with kidney transplantation, immunosuppressive drugs account for a large proportion of costs, and are mostly combined with drugs to find more effective and less adverse reactions, lower prices of immunosuppressive treatment programs to improve the quality of life in renal transplant patients and save more kidney function The life of failing patients is of great importance.