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目的:探讨胰十二指肠切除术(PD)门静脉-肠系膜上静脉(PSMV)切除重建时围静脉阻断期管理策略及其影响。方法:回顾性分析2010年1月至2020年12月在首都医科大学附属北京朝阳医院西院、朝阳市中心医院、朝阳市第二医院、日照市中心医院及滨州市第二人民医院行PD的137例胰腺癌患者资料，其中男性83例，女性54例，平均年龄61.8岁。将联合PSMV切除重建的42例纳入血管重建组(采用围静脉阻断期管理策略)，无血管侵犯的95例纳入对照组。比较两组手术时间、术中出血量、术后住院时间、再次手术及围手术期死亡率以及术后并发症等。结果:137例患者PD均顺利完成。血管重建组PSMV阻断时间15～120 min，中位数30 min。血管重建组手术时间380(330，465)min、术中出血量725(500，1 000)ml、术后住院时间21.0(16.0，28.0)d，均高于对照组305(280，340)min、400(300，500)ml、18.0(14.0，24.5)d，差异有统计学意义(均n P0.05)。血管重建组胰瘘、腹腔积液及感染、肺部感染发生率高于对照组，差异有统计学意义(n P0.05)。n 结论:PSMV切除重建可明显增加PD术后胰瘘、腹腔积液及感染等并发症发生率，科学系统的围静脉阻断期管理策略对于促进术后顺利恢复，降低围手术期死亡率具有重要意义。“,”Objective:To explore the perivenous blocking management strategy for portal vein-superior mesenteric vein (PSMV) resection and reconstruction and its effect on postoperative complications in patients undergoing pancreaticoduodenectomy (PD).Methods:The data of 137 patients with pancreatic cancer treated with PD in Beijing Chaoyang Hospital Affiliated to Capital Medical University, Chaoyang Central Hospital, the Second Hospital of Chaoyang, Rizhao Central Hospital, the Second People's Hospital of Binzhou from January 2010 to December 2020 were collected. There were 83 males and 54 females with an average age of 61.8 years. There were 42 patients in the reconstruction group and 95 patients in the control group. The main intraoperative indexes and postoperative complications were compared between the two groups with the aim to review our experience in PSMV resection and reconstruction by using the perivenous blocking management strategy.Results:PD was successfully completed in 137 patients in the reconstruction group, the PSMV blocking time was 15-120 min, with a median of 30 min. The operation time 380 (330, 465) min, intraoperative blood loss 725 (500, 1000) ml, and postoperative hospital stay 21.0 (16.0, 28.0) d in the reconstruction group were significantly higher than those of control group [305 (280, 340) min, 400 (300, 500) ml and 18.0 (14.0, 24.5) d] (all n P0.05). The incidence of pancreatic fistula, peritoneal effusion and infection, pulmonary infection of the reconstruction group was significantly higher than those of the control group (n P0.05).n Conclusions:PSMV resection and reconstruction significantly increased the incidences of complication after PD, including pancreatic fistula, peritoneal effusion/infection and pulmonary infection. The perivenous blocking management strategy significantly promoted smooth postoperative recovery and effectively reduced morbidity rates of postoperative bleeding and mortality after PSMV resection and reconstruction in PD.