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我们选用大鼠复制肠系膜上动脉夹闭性(SMAO)休克模型,观察尿蛋白酶抑制剂和抑肽酶对心、肝、小肠组织中氧自由基产生的抑制作用。结果发现:应用尿蛋白酶抑制剂后,心、肝和小肠组织内丙二醛含量明显降低,血清中β-葡萄糖醛酸酶和酸性磷酸酶的含量也明显减少,且用药后动物心脏和肝组织病理改变轻微。结果提示:尿蛋白酶抑制剂抑制休克时氧自由基的产生,保护细胞内溶酶体的破坏及溶酶体酶的释放,从而发挥其抗休克作用。
We selected rat replication superior mesenteric artery occlusion (SMAO) shock model to observe the inhibitory effect of urinary protease inhibitors and aprotinin on heart, liver and small intestine oxygen free radicals. The results showed that: the application of urinary proteinase inhibitor, heart, liver and intestinal tissue MDA content decreased significantly, serum β-glucuronidase and acid phosphatase levels were significantly reduced, and the use of animal heart and liver tissue Pathological changes slightly. The results suggest that: urinary protease inhibitors inhibit the generation of oxygen free radicals in shock, protect the destruction of intracellular lysosomes and lysosomal enzyme release, which play its anti-shock effect.