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目的 对比柔肝健脾药物与健脾药物对大鼠溃疡性结肠炎(UC)模型肠管P物质(SP)和血管活性肠肽(VIP)的影响。方法 采用实验大鼠分组进行实验观察。结果:模型组SP、VIP明显增高,治疗组较模型组含量明显降低(P<0.01),与对照组比较,差异有显著性(P<0.01)。结论 柔肝健脾药物是通过改善大脑皮层的紊乱状态,调节植物神经功能而调节SP、VIP的含量。
Objective To compare the effects of Rouganjianpi drugs and spleen-enhancing drugs on intestinal substance P (SP) and vasoactive intestinal peptide (VIP) in rat ulcerative colitis (UC) model. Methods Experimental rats were divided into groups for experimental observation. Results: SP and VIP in the model group were significantly higher, and the content in the treatment group was significantly lower than that in the model group (P<0.01). Compared with the control group, the difference was significant (P<0.01). Conclusion Rouganjianpi medicine can regulate the content of SP and VIP by improving the disorder of cerebral cortex and regulating the function of autonomic nerves.