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尽管治疗哮喘的药物越来越多,但哮喘死亡率并无明显改善。近年已经认识到气道内细胞免疫反应导致哮喘患者炎症持续存在,引起气道反应性增加。吸入皮质激素对中度哮喘有很好效果,但其作用机制尚不明。通过观察激素应用前后生理学及免疫病理学变化,了解激素对哮喘气道内细胞免疫反应的作用。 6例单独用β_2激动剂能控制症状的哮喘患者,吸入糖皮质激素丁地去炎松(Budesonide)400μgbid,3个月,治疗前后检查肺功能,吸入嗽必妥后
Despite the increasing use of medications to treat asthma, there has been no significant improvement in asthma mortality. In recent years, it has been recognized that the airway cellular immune response leads to the persistence of inflammation in asthmatic patients, resulting in increased airway responsiveness. Inhaled corticosteroids have a good effect on moderate asthma, but its mechanism of action is not yet known. By observing the hormone before and after the application of physiology and immunopathological changes to understand the role of hormones in the airway airway immune response. Six patients with asthma who were able to control their symptoms with β 2 agonist alone, inhaled corticosteroid 400 μg bid for 3 months, before and after treatment, inhaled cough after treatment