产生新生儿黄疸的主要原因是由于新生儿肝功能尚不完善,对胆红素的葡萄糖醛酸结合能力尚低;肝脏细胞中Y和Z蛋白质不足,亦降低了肝细胞对胆红素的摄取能力。而苯巴比妥是肝脏药物代谢酶的诱导剂,它能激活肝脏药物代谢酶的活性,增加胆红素与葡萄糖醛酸结合能力,其次它还可增加肝细胞膜对胆红素的通透 The main reason for neonatal jaundice is that neonatal liver function is not yet perfect, glucuronidation of bilirubin is still low; lack of Y and Z protein in liver cells, but also reduce the liver cells to bilirubin intake ability. Phenobarbital is an inducer of hepatic drug-metabolizing enzymes, which can activate the activity of hepatic drug-metabolizing enzymes and increase the binding capacity of bilirubin and glucuronic acid. Secondly, it can also increase the permeability of liver cell membrane to bilirubin