【摘 要】
：
Coronavirus disease 2019(COVID-19),the disease caused by infection with se-vere acute respiratory syndrome coron-avirus 2(SARS-CoV-2),has developed into a global pandemic that continues to pose an enormous threat to public health and the global economy.Si
【机 构】
：
Key Laboratory of Combinatorial Biosynthesis and Drug Discovery,Ministry of Education and School of
论文部分内容阅读
Coronavirus disease 2019(COVID-19),the disease caused by infection with se-vere acute respiratory syndrome coron-avirus 2(SARS-CoV-2),has developed into a global pandemic that continues to pose an enormous threat to public health and the global economy.Since the first SARS-CoV-2 genome was released[1],thousands of genetic variants have been identified in SARS-CoV-2 strains isolated from worldwide patients.Some variants in the spike(S)protein have been re-ported to be associated with functional changes in viral transmissibility or viral loads,such as the D614G variant[2,3],the N501Y change,the P681H substitu-tion and deletion of AH69-AV70[4].However,there is currently little direct evidence linking the genomic variants and clinical severity of COVID-19.
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庄子是前无古人、后无来者的大文学家,恣肆汪洋、上天人地、妙想奇思、鲲鹏盖世.最有名的是知不知鱼之辩:rn庄子曰:“鯈鱼出游从容,是鱼之乐也.”惠子曰:“子非鱼,安知鱼之乐?”庄子曰:“子非我,安知我不知鱼之乐?”惠子曰:“我非子,固不知子矣;子固非鱼也,子之不知鱼之乐全矣!”庄子曰:\"请循其本.