论文部分内容阅读
目的 研究血小板活化和内皮细胞损害对恶性肿瘤病情和预后的影响。方法 采用放射免疫法和酶联免疫法测定78例恶性肿瘤和40例正常人血浆血栓烷B2(TXB2),血小板α-颗粒膜蛋白(GMP-140),血管性血友病因子(vWF),环磷酸鸟苷(cGMP)和血清纤维结合蛋白(FN)含量。结果 1)肠癌、肺癌、肝癌组TXB2、GMP-140、vWF和cGMP升高、肠癌、肺癌FN下降。2)肿瘤组cGMP与TXB2、GMP-140、vWF之间均呈正相关。3)肿瘤组合并感染FN下降;已转移FN下降,其余指标升高,手术后GMP-140、vWF和cGMP下降,FN升高。结论 恶性肿瘤患者存在血小板活化和内皮细胞损害,二者影响恶性肿瘤的转移和预后。
Objective To study the effects of platelet activation and endothelial cell damage on the condition and prognosis of malignant tumors. Methods The plasma levels of thromboxane B2 (TXB2), platelet α-granule membrane protein (GMP-140), von Willebrand factor (vWF) in 78 malignant tumors and 40 normal controls were determined by radioimmunoassay and enzyme-linked immunosorbent assay CGMP and fibronectin (FN) levels were measured. Results 1) The levels of TXB2, GMP-140, vWF and cGMP in colorectal cancer, lung cancer and hepatocellular carcinoma group were increased, while the FN in colorectal cancer and lung cancer was decreased. 2) The tumor group cGMP and TXB2, GMP-140, vWF were positively correlated. 3) The combination of tumor and infection decreased FN; FN decreased, the other indicators increased, GMP-140, vWF and cGMP decreased, FN increased after surgery. Conclusion There are platelet activation and endothelial cell damage in patients with malignant tumors, both of which affect the metastasis and prognosis of malignant tumors.