磺脲类药物继发失效(SF)是2型糖尿病(DM)治疗过程中的难题之一。据报道,SF年发生率为5%～10%[1]。我们于2001年4月至2005年4月观察了178例SF的2型DM患者改变治疗方案后的临床疗效,报告如下。对象与方法1.一般资料:本组178例,男86例,女92例;年龄26～72岁,平均(54±8)岁;均符合19 Sulfonylurea secondary failure (SF) is one of the problems in the treatment of type 2 diabetes mellitus (DM). It is reported that the incidence of SF is 5% to 10% [1]. We observed from April 2001 to April 2005 178 patients with type 2 DM SF treatment of clinical efficacy after the change, the report is as follows. Subjects and methods 1. General information: 178 cases in this group, 86 males and 92 females; aged 26 to 72 years, mean (54 ± 8) years; are in line with 19