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为了解维生素Ｋ在尿石形成中作用，用超滤法分离正常人和草酸钙肾结石患者尿中大分子物；结合草酸耐受试验，检测肾结石患者应用维生素Ｋ前后尿不同分子量物质的草酸耐受量。结果：正常人及肾结石患者尿分子量１００００～３００００大分子物草酸耐受量最高；肾结石患者较正常人草酸耐受量低（分别为２．７２±０．７４ｍｌ和３．７５±０．３５ｍｌ，Ｐ＜０．０５）；肾结石患者应用维生素Ｋ后尿１００００～３００００大分子物草酸耐受量增加（３．１９±０．５７ｍｌ，Ｐ＜０．０５）。提示尿中草酸钙结石抑制物主要为分子量１００００～３００００的大分子物，维生素Ｋ应用后明显改善肾结石患者尿抑制作用
In order to understand the role of vitamin K in the formation of urolithiasis, urine and macromolecules in normal and calcium oxalate nephrolithiasis were separated by ultrafiltration. Combined with oxalic acid tolerance test, urinary oxalate Tolerance. Results: Normal and renal calculus patients had the highest oxalic acid tolerance of 10,000 to 30,000 macromolecules. The patients with kidney stones had lower tolerance to oxalic acid (2.72 ± 0.74ml and 3.75 ± 0, respectively). 35ml, P <0.05). Oxalic acid tolerance of 10000 ~ 30000 macromolecules in patients with kidney stones increased (3.19 ± 0.57ml, P <0.05) after vitamin K administration. Prompt urinary calcium oxalate stones inhibitors mainly for the molecular weight of 10,000 to 30,000 macromolecules, vitamin K after application significantly improve the urinary inhibition of renal stone patients