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目的:观察咪唑克生对吗啡镇痛及吗啡所致耐受和躯体依赖的影响.方法:采用小鼠醋酸扭体实验和55℃热板实验观察咪唑克生对基础痛阈及吗啡镇痛作用的影响;采用小鼠热辐射甩尾实验和小鼠55℃热板实验观察咪唑克生对吗啡耐受形成过程的影响;采用大鼠、小鼠身体依赖模型观察咪唑克生对吗啡所致身体依赖的影响.结果:咪唑克生(3-9mg/kg)能显著降低小鼠基础痛阈,抑制吗啡镇痛;加重吗啡所致耐受;诱发大、小鼠发生戒断综合征.结论:咪唑啉受体参与痛阈形成;咪唑克生能抑制吗啡镇痛,加重吗啡所致耐受;并诱发吗啡依赖性动物发生戒断综合征.
Objective: To observe the effect of midazolam on morphine analgesia and morphine-induced tolerance and somatic dependence.METHODS: Mice were treated with acetic acid writhing test and 55 ℃ hot plate test to observe the effect of midazolam on the basis of pain threshold and morphine analgesia The effects of midazolam on the morphogenesis of morphine tolerance were observed by using the mouse heat radiation tail flick test and the mouse hot plate test at 55 ℃. The body-dependent model of rats and mice was used to observe the effects of midazolam on morphine- (3-9 mg / kg) significantly reduced the basal pain threshold, inhibited the morphine analgesia, increased the tolerance induced by morphine, and induced withdrawal syndrome in both large and small mice.Conclusion: Imidazoline receptors participate in the formation of pain threshold; midazolam can inhibit morphine analgesia and exacerbate morphine-induced tolerance; and induce morphine-dependent animals with withdrawal syndrome.