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目的口腔鳞癌临床最多见的是高、中分化程度的鳞癌,低度分化极为罕见,癌细胞的增殖活性和对化疗药物的耐药性与愈后关系紧密,多药耐药糖蛋白p-gp170和人抗增殖核细胞抗原ki-67较具代表性,检测多药耐药糖蛋白p-gp170和人抗增殖核细胞抗原ki-67在不同分化的口腔鳞癌中的表达,以探讨二者与口腔鳞癌分化程度的关系。方法采用免疫组织化学SP法检测p-gp170和ki-67在41例高分化和17例中分化口腔鳞癌中的表达,p-gp170在高、中分化的口腔鳞癌表达关系采用χ2检验,ki-67在高、中分化的口腔鳞癌表达关系采用秩和检验。结果 p-gp170在高分化和中分化鳞癌之间的关系应用卡方检验的方法进行相关分析,χ2值为15.172,P值为0.001,差异有统计学意义;ki-67高分化组平均值为5.40,中分化组为10.34,ki-67采用秩和检验,Z值为-3.567,P值为0.000,差异有统计学意义。结论口腔鳞癌恶性程度越高,耐药指标多药耐药糖蛋白p-gp170的表达水平越高,其增殖指标人抗增殖核细胞抗原ki-67表达水平越高,二者呈正相关。
Objective Oral squamous cell carcinoma is the most common high-grade, moderately differentiated squamous cell carcinoma, low differentiation is extremely rare, the proliferation of cancer cells and chemotherapy drug resistance and prognosis are closely related to multidrug resistance glycoprotein p -gp170 and human antiproliferative cell antigen ki-67 is more representative, to detect the expression of multidrug resistance glycoprotein p-gp170 and human antiproliferative cell antigen ki-67 in differentiated oral squamous cell carcinoma The relationship between them and the differentiation of oral squamous cell. Methods The expression of p-gp170 and ki-67 in 41 cases of well differentiated and 17 cases of moderately differentiated OSCC was detected by immunohistochemical SP method. The expression of p-gp170 in high and differentiated OSCC was analyzed byχ2 test, ki-67 expression in high and differentiated oral squamous cell carcinoma using rank sum test. Results The relationship between p-gp170 and well-differentiated and moderately differentiated squamous cell carcinoma was analyzed by chi-square test (χ2 = 15.172, P = 0.001), and the difference was statistically significant. The average value of ki- Was 5.40, middle differentiation group was 10.34, ki-67 rank sum test, Z value was -3.567, P value was 0.000, the difference was statistically significant. Conclusion The higher the malignant degree of oral squamous cell carcinoma, the higher the expression level of multidrug resistance protein p-gp170 is, the higher the expression level of anti-proliferating cell antigen ki-67 is.