目的:探讨MCI-186干预实验性自身免疫性脑脊髓炎(EAE)的疗效及机制。方法:PLP_(139-151)诱发EAE,分别在EAE发病前后予MCI-186治疗,观察病程;MRI观察病灶;免疫组化检测诱导型一氧化氮合酶(iNOS)和硝基酪氨酸(NT)表达;TUNEL法检测细胞凋亡。结果:EAE发病前MCI-186干预可延迟发病,减轻炎症,抑制iNOS、NT的表达及细胞凋亡;EAE发病后MCI-186治疗减轻炎症,抑制病情进展。结论:MCI-186治疗EAE有效,通过保护血脑屏障、抑制炎症和自由基损伤起作用。 Objective: To investigate the therapeutic effect and mechanism of MCI-186 on experimental autoimmune encephalomyelitis (EAE). Methods: EAE was induced by PLP_ (139-151) and treated with MCI-186 before and after the onset of EAE. The course of disease was observed. The lesions were observed by MRI. The expressions of iNOS and nitrotyrosine (iNOS) NT); TUNEL method was used to detect the apoptosis. Results: MCI-186 pretreatment can delay the onset, reduce the inflammation, inhibit the expression of iNOS and NT, and induce the apoptosis of MCE-186 cells. EAI can reduce the inflammation and inhibit the progression of the disease. CONCLUSION: MCI-186 is effective in the treatment of EAE and plays a role in protecting the blood-brain barrier and inhibiting inflammation and free radical damage.