1959年Thomas首次报告骨髓功能衰竭患者经胎肝细胞输注治疗,未见到任何副作用。随后一些作者将胎肝细胞输注用于临床治疗再障和急性白血病,部分患者的病情有不同程度的改善。近年来,国外少数作者对急性白血病试用胎肝造血干细胞移植(FLT)。在移植前给以强烈化疗和全身照射,争取杀灭更多白血病细胞,严重抑制免疫功能,以期胎肝造血干细胞有可能植上。目前,国内胎肝来源较组织配型(HLA)相配的骨髓移植供者易于获得,且极少发生 Thomas first reported in 1959 patients with bone marrow failure transfusion of fetal liver cells, did not see any side effects. Later, some authors transfused fetal liver cells for clinical treatment of aplastic anemia and acute leukemia, and some patients had varying degrees of improvement. In recent years, few foreign authors tested fetal liver allogeneic hematopoietic stem cell transplantation (FLT) for acute leukemia. Before transplantation to give strong chemotherapy and systemic irradiation, strive to kill more leukemia cells, severe inhibition of immune function, in order to fetal liver hematopoietic stem cells may be planted. At present, bone marrow transplantation donors matching fetal tissue sources (HLA) in China are easy to obtain and rarely occur