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1 抗磷脂抗体及抗磷脂综合征 1．1 抗磷脂抗体(Antiphospholipid antibody,aPL) aPL是一族针对带负电荷磷脂或带负电荷磷脂与蛋白的复合物的异质性自身抗体的总称,是诊断抗磷脂综合征 (Antiphospholipid Syndrome,APS)的条件之一。目前已知的aPL的靶抗原有三大类:①磷脂:心磷脂、磷脂酰丝氨酸、磷脂酰乙醇胺、磷脂酰肌醇;②磷脂-蛋白复合物:β2糖蛋白Ⅰ(β2-GP Ⅰ)、凝血酶
1 Antiphospholipid Antibodies and Antiphospholipid Syndrome 1.1 Antiphospholipid Antibodies (aPL) aPL is a generic term for a group of heterogeneous autoantibodies against negatively charged phospholipids or complexes of negatively charged phospholipids and proteins that are diagnostic Antiphospholipid syndrome (Antiphospholipid Syndrome, APS) one of the conditions. Currently known aPL target antigen has three broad categories: ① phospholipids: cardiolipin, phosphatidylserine, phosphatidylethanolamine, phosphatidylinositol; ② phospholipid - protein complex: β2-glycoprotein Ⅰ (β2-GP Ⅰ), coagulation Enzymes