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合成鱼腥草素为我国自创的抗菌消炎药,在水中溶解度低,20℃时为0.137%。对药物吸收有重大关系的同质多晶现象,目前尚无人进行研究。由实验室及生产车间分别制得结晶Ⅰ、Ⅱ、Ⅲ。结晶Ⅰ系用50%乙醇重结晶(室温自然冷却);晶Ⅱ系在 DMF 重结晶(室温自然冷却);晶Ⅲ系50%乙醇结晶(机械搅拌),最后用乙酸乙酯洗净,未重结晶,系车间大量生产成品。上述不同结晶经热分析(DTA 及 CTG)、偏光显微镜、红外光谱、X 射线粉末衍射等测试,特别是 X 射线粉末衍射结果证明是结晶结构不同的同一物质。
Houttuynin synthesis for our own anti-bacterial anti-inflammatory drugs, low solubility in water, 20 ℃, 0.137%. There is no research on the phenomenon of polymorphism that has a significant relationship with drug absorption. Crystallization Ⅰ, Ⅱ and Ⅲ are respectively made by laboratory and production workshop. Crystalline Ⅰ was recrystallized from 50% ethanol (cooled at room temperature); Recrystallization of II from DMF (natural cooling at room temperature); Crystallization of III from 50% ethanol (mechanical stirring), and finally washing with ethyl acetate, Crystallization, the Department of mass production of finished products. The above-mentioned different crystals were tested by thermal analysis (DTA and CTG), polarized light microscopy, infrared spectroscopy and X-ray powder diffraction. The X-ray powder diffraction results, in particular, proved that the same crystal with the same crystal structure was obtained.