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作者对近年来治疗龋齿和牙周病的药物缓释转运系统文献进行了综述。开发氟化物缓释制剂的一般途径有二:其一将药丸、微囊、条状药用粘合剂固定于牙齿表面。其二使用具有粘性的药物载体,如涂剂。前者的氟化物含量较高,作用时间长;后者(涂剂)可由病人自己用药,无需牙科医生帮助。另外,涂剂对龋齿表面的小坑、齿间裂缝等处有穿透力。一种贴在牙齿表面的氟化钠控释装置是由羟乙基异丁烯酸和甲基异丁烯酸共聚物的水凝胶制成。装置的核心部分是氟化钠贮库;
The authors reviewed the recent literature on drug delivery systems for the treatment of dental caries and periodontal disease. There are two general ways to develop sustained release formulations of fluoride: one is to fix the pellets, microcapsules and strip-shaped adhesives on the tooth surface. The second uses a sticky pharmaceutical carrier, such as a coating. The former has a high fluoride content and a long duration of action; the latter (paints) can be administered by the patient himself without the help of a dentist. In addition, the paint on the surface of cavities pits, interdental cracks, etc. Department of penetration. A sodium fluoride controlled release device attached to the tooth surface is made from a hydrogel of hydroxyethyl methacrylate and methyl methacrylate copolymer. The heart of the device is a sodium fluoride reservoir;