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研究牛磺胆酸钠和牛磺鹅去氧胆酸钠的药理作用。方法：采用浓氨水引咳法、酚红排泌法、鼠耳肿胀及大鼠足跖肿胀法，观察动物给药后，牛磺胆酸钠和牛磺鹅去氧胆酸钠镇咳、祛痰和抗炎作用。结果：牛磺胆酸钠和牛磺鹅去氧胆酸钠可明显抑制氨水刺激所致小鼠咳嗽，延长咳嗽潜伏期；促进小鼠呼吸道分泌，增加酚红排泌量；抑制二甲苯致小鼠耳朵肿胀及角叉菜胶致大鼠足肿胀。结论：牛磺胆酸钠和牛磺鹅去氧胆酸钠均具有明显的镇咳、祛痰和抗炎作用。推测它们为蛇胆汁和鸡胆汁中的主要有效成分之一。
To study the pharmacological effects of sodium taurocholate and sodium taurochenodeoxycholate. Methods: Concentrated ammonia coughing method, phenol red excretion method, mouse ear swelling, and rat paw edema were used to observe the effect of sodium taurocholate and taurochenodeoxycholic acid antitussive and antitussive after animal administration. And anti-inflammatory effects. Results: Sodium taurocholate and taurochenodeoxycholic acid sodium can significantly inhibit the cough induced by ammonia-stimulating mice, prolong the incubation period of cough, promote the secretion of respiratory tract in mice, increase the excretion of phenol red, and inhibit xylene-induced mouse ears. Swelling and foot swelling in rats caused by carrageenan. Conclusion: Sodium taurocholate and sodium taurodeoxycholate have obvious antitussive, expectorant and anti-inflammatory effects. It is speculated that they are one of the main active ingredients in snake bile and chicken bile.