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目的:探讨食管癌患者病理切片中N GAL蛋白的表达及其临床意义。方法:运用免疫组化技术对57例食管癌患者病理切片及对照组中的32例正常食管切片NGAL表达情况进行检测。结果:通过免疫组化染色NGAL在57例食管癌患者病理切片中皆可见阳性表达,在癌巢周围及癌巢中央的细胞易见明显的强阳性表达,对照组NGAL阳性表达细胞比例少,强度弱,差异具有统计学意义(P<0.05)。结论:NGAL基因在人食管上皮细胞向食管癌细胞恶性转化的过程中显著过表达,提示NGAL基因可能是一种新的食管癌癌变相关基因。
Objective: To investigate the expression of N-GAL in pathological sections of patients with esophageal cancer and its clinical significance. Methods: Immunohistochemical technique was used to detect the expression of NGAL in 32 cases of esophageal cancer patients and 32 cases of normal esophageal squamous cell carcinoma. Results: The positive expression of NGAL was found in all the 57 cases of esophageal cancer by immunohistochemical staining. The strong positive expression was observed in the cells around the cancer nest and in the center of the cancer nest. The proportion of NGAL positive cells in the control group was less, Weak, the difference was statistically significant (P <0.05). CONCLUSION: NGAL gene is overexpressed in the process of malignant transformation of human esophageal epithelial cells into esophageal cancer cells, suggesting that NGAL gene may be a new carcinogenesis-related gene of esophageal cancer.